A Simulation study of physiological factors affecting pharmacokinetic behaviour of organic solvent

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<title>Simulation study of physiological factors affecting pharmacokinetic behaviour of organic solvent</title>
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<title>British journal of industrial medicine</title>
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<name type="personal" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="MAPA20080016975">
<namePart>Sato, Akio</namePart>
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<dateIssued encoding="marc">1991</dateIssued>
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<abstract displayLabel="Summary">This paper discusses how physiological factors may influence the pharmacokinetic behaviour of inhaled organic solvent vapours, especially in relation to monitoring of biological exposure. To illustrate the discussion a computer based physiological pharmacokinetic model was used describing quantitatively the influence of body size, body fat content, and sex on the pharmacokienetic behaviour of trichloroethylene. Body build (body weight and body fat content), also affected the pharmacokinetic behaviour of this solvent</abstract>
<note type="statement of responsibility">A. Sato... [et al.]</note>
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<topic>Contaminantes químicos</topic>
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<topic>Enfermedades pulmonares</topic>
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<topic>Enfermedades profesionales</topic>
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<topic>Fisiología</topic>
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<topic>Disolventes orgánicos</topic>
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<topic>Tricloroetileno</topic>
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<topic>Epidemiología</topic>
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<topic>Vapores orgánicos</topic>
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<topic>Análisis clínicos</topic>
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<title>British journal of industrial medicine</title>
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<publisher>London and Margate</publisher>
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<text>nº 5, May 1991 ; p. 342-347</text>
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