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Effects of ethanol and phenobarbital treatments on the pharmacokinetics of tolueno in rats
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MAP20071017020
Wang, Rui-Sheng ‌
Effects of ethanol and phenobarbital treatments on the pharmacokinetics of tolueno in rats / Rui-Sheng Wang, Tamie Nakajima
Sumario: In this present study, it investigated the in vivo metabolic pattern of tolueno in rats, especially the pattern of urinary excretion of toluene metabolites, at seven exposure concentrations ranging betwen 50 and 4000 ppm. The effect of ethanol and phenobarbital treatments on toluene pharmacokinetics was also studied in that these two chemical induce different types of cytochrome P-450 that are known to be insolved in toluene metabolisme in vitro
En: British journal of industrial medicine. - London and Margate. - nº 2, February 1992 ; p. 104-112
1. Medicina laboral ‌. 2. Experimentos ‌. 3. Reacciones metabólicas ‌. 4. Contaminantes químicos ‌. 5. Tolueno ‌. 6. Etanol ‌. I. Nakajima, Tamie ‌. II. Title. III. Título: British journal of industrial medicine.