Variations of some parameters of enzyme induction in chemical workers

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      <subfield code="a">Variations of some parameters of enzyme induction in chemical workers</subfield>
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      <subfield code="a">Several parameters related to mono-oxygenase activity were followed in a population of chemical workers and controls. Workers exposed to toluene and xylene had a significant increase of urinary glucaric acid, that was correlated with hippuric acid excretion. On the other hand, workers exposed to pigments showed a marked increase of antipyrine half-life. A dose-related decrease of liver N-demethylase was induced in rats by the administration of a mixture of three of the pigments in use in the plant. The exposure to different chemicals in the workplace seemed to induce a complicated variation of mono-oxygenase levels, some enzyme being inhibited and others induced in the same group of workers</subfield>
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      <subfield code="g">nº 1, 1982 ; p. 27-32</subfield>
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