Some effects of jet-lag and their alleviation by melatonin

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      <subfield code="a">Some effects of jet-lag and their alleviation by melatonin</subfield>
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      <subfield code="a">Seventeen healthy volunteers were flown from London to San Francisco and remained there for 14 days prior to flight home. Subjects took melatonin or placebo in a double-blind design, at 18.00h local time for three days before the return flight and at bedtime in Great Britain for four days. These data suggest that MT can alleviate jet-lag after Eastward flight over eight time zones. Presumably its affects are primarily on sleep latency, quality, and directly or indirectly on some hormonal rhythms</subfield>
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      <subfield code="g">Vol. 30, nº 9, September 1987 ; p. 1379-1393</subfield>
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