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The Impact of cytochrome P450 2E1-dependent metabolic variance on a risk-relevant pharmacokinetic outcome

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001  MAP20071504938
003  MAP
005  20080418124434.0
007  hzruuu---uuuu
008  040218e20031201usa|||| | |00010|eng d
040  ‎$a‎MAP‎$b‎spa
084  ‎$a‎873
24514‎$a‎The Impact of cytochrome P450 2E1-dependent metabolic variance on a risk-relevant pharmacokinetic outcome‎$c‎John C. Lipscomb ... [et al.]
5208 ‎$a‎Risk assessment include assumptions about sensitive subpopulations, such as the fraction of the general population that is sensitive and the extent that biochemical or physiological attributes influence sensitivity. Uncertainty factor account for both pharmacokinetic (PK) and pharmacodynamic (PD) components, allowing the inclusin of risk-relevant information to replace default assumptions about PK and PD variance (uncertainty)
65011‎$0‎MAPA20080575083‎$a‎Citrocromo P-450
65011‎$0‎MAPA20080537043‎$a‎TCP
65001‎$0‎MAPA20080576615‎$a‎Medicina laboral
65011‎$0‎MAPA20080565541‎$a‎Epidemiología
65011‎$0‎MAPA20080577155‎$a‎Plantas químicas
65001‎$0‎MAPA20080570484‎$a‎Riesgo laboral
7001 ‎$0‎MAPA20080198640‎$a‎Lipscomb, John C.
7730 ‎$w‎MAP20077000345‎$t‎Risk analysis : an international journal‎$d‎New York and London : Society for Risk Analysis‎$g‎Vol. 23, nº 6, December, 2003 ; p. 1221-1238