The Impact of cytochrome P450 2E1-dependent metabolic variance on a risk-relevant pharmacokinetic outcome

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<title>Impact of cytochrome P450 2E1-dependent metabolic variance on a risk-relevant pharmacokinetic outcome</title>
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<namePart>Lipscomb, John C.</namePart>
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<abstract>Risk assessment include assumptions about sensitive subpopulations, such as the fraction of the general population that is sensitive and the extent that biochemical or physiological attributes influence sensitivity. Uncertainty factor account for both pharmacokinetic (PK) and pharmacodynamic (PD) components, allowing the inclusin of risk-relevant information to replace default assumptions about PK and PD variance (uncertainty)</abstract>
<note type="statement of responsibility">John C. Lipscomb ... [et al.]</note>
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<title>Risk analysis : an international journal</title>
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<publisher>New York and London : Society for Risk Analysis</publisher>
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<text>Vol. 23, nº 6, December, 2003 ; p. 1221-1238</text>
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