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Framework for evaluation of physiologically-based pharmacokinetic models for use in safety or risk assessment

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008  050314e20041201usa|||| | |00010|eng d
040  ‎$a‎MAP‎$b‎spa
084  ‎$a‎7
1001 ‎$0‎MAPA20080127145‎$a‎Clark, Leona H.
24510‎$a‎Framework for evaluation of physiologically-based pharmacokinetic models for use in safety or risk assessment‎$c‎Leona H. Clark, R. Woodrow Setzer, and Hugh A. Barton
5208 ‎$a‎Proposed applications of increasinggly sophisticated biologically-based computational models, such as physiologically-based pharmacokinetic models, raise the issue of how to evaluate whether the models are adequate for proposed uses, including safety or risk assessment
65011‎$0‎MAPA20080604394‎$a‎Valoración de riesgos
65011‎$0‎MAPA20080602635‎$a‎Modelos de evaluación
65001‎$0‎MAPA20080588953‎$a‎Análisis de riesgos
65001‎$0‎MAPA20080552619‎$a‎Seguridad
65011‎$0‎MAPA20080589004‎$a‎Análisis matemático
65001‎$0‎MAPA20080601522‎$a‎Evaluación de riesgos
65011‎$0‎MAPA20080572181‎$a‎Farmacocinética
65011‎$0‎MAPA20080570507‎$a‎Riesgo químico
7001 ‎$0‎MAPA20080232801‎$a‎Setzer, Woodrow R.
7001 ‎$0‎MAPA20080122911‎$a‎Barton, Hugh A.
7730 ‎$w‎MAP20077000345‎$t‎Risk analysis : an international journal‎$d‎New York and London : Society for Risk Analysis‎$g‎Vol. 24, nº 6, December 2004 ; p. 1697-1717