Mineral fibres : correlation between oxidising surface activity and DNA base hydroxylation

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      <subfield code="a">Mineral fibres</subfield>
      <subfield code="b">: correlation between oxidising surface activity and DNA base hydroxylation</subfield>
      <subfield code="c">A. Nejjari... [et al.]</subfield>
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      <subfield code="a">In relation to their potential genotoxic propertiers, the ability of inorganic particles to induce activated species of oxygen with strong oxidative properties can be studied by various methods. In this study the oxidative surface properties of 10 different natural and synthetic mineral fibres were investigate by: an electron paramagnetic resonance technique in which formate was used to trap oxidative species; and a high performance liquid chromatography based method in which deoxyguanosine was used as a trapping agent and the formation of 8-hydroxydeoxygyanosine was analysed. Ground iron-containing fibres such as crocidolite and amosite were the most reactive, whereas fibres without iron were completely inactive. A good correlation was found when the results from the two methods were compared</subfield>
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      <subfield code="a">Fibra mineral</subfield>
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      <subfield code="a">British journal of industrial medicine</subfield>
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      <subfield code="t">British journal of industrial medicine</subfield>
      <subfield code="d">London and Margate</subfield>
      <subfield code="g">nº 6, June 1993 ; p. 501-504</subfield>
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