What makes silica toxic?

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<title>What makes silica toxic?</title>
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<title>British journal of industrial medicine</title>
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<name type="personal" usage="primary" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="MAPA20080008697">
<namePart>Bagchi, N.</namePart>
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<dateIssued encoding="marc">1992</dateIssued>
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<abstract displayLabel="Summary">Published data suggest that particle charge could be related to its toxicity. Respirable particles containing silica were therefore collected in foundries and their charge measured. These particles carried high levels of positive charge that were related to low humidity. incubating these particles with pulmonary macrophages from mice produced detectable activities of collagenase, aprecursor of silicosis. These experiments confirm that the toxicity of silica particles is likely to be because of the positive charge they carry</abstract>
<note type="statement of responsibility">N. Bagchi</note>
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<topic>Medicina laboral</topic>
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<topic>Enfermedades profesionales</topic>
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<subject authority="lcshac" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="MAPA20080552671">
<topic>Silicosis</topic>
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<subject authority="lcshac" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="MAPA20080542313">
<topic>Sílice</topic>
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<topic>Polvo de sílice</topic>
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<topic>Experimentos</topic>
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<topic>Toxicidad</topic>
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<title>British journal of industrial medicine</title>
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<publisher>London and Margate</publisher>
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<text>nº 3, March 1992 ; p. 163-166</text>
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