Centro de Documentacion de Fundación MAPFRE - Framework for evaluation of physiologically-based pharmacokinetic models for use in safety or risk assessment

MAP20071506499

Framework for evaluation of physiologically-based pharmacokinetic models for use in safety or risk assessment / Leona H. Clark, R. Woodrow Setzer, and Hugh A. Barton

Proposed applications of increasinggly sophisticated biologically-based computational models, such as physiologically-based pharmacokinetic models, raise the issue of how to evaluate whether the models are adequate for proposed uses, including safety or risk assessment

En: Risk analysis : an international journal. - New York and London : Society for Risk Analysis. - Vol. 24, nº 6, December 2004 ; p. 1697-1717

1. Valoración de riesgos . 2. Modelos de evaluación . 3. Análisis de riesgos . 4. Seguridad . 5. Análisis matemático . 6. Evaluación de riesgos . 7. Farmacocinética . 8. Riesgo químico . I. Setzer, Woodrow R. . II. Barton, Hugh A. . III. Título.