Framework for evaluation of physiologically-based pharmacokinetic models for use in safety or risk assessment

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<title>Framework for evaluation of physiologically-based pharmacokinetic models for use in safety or risk assessment</title>
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<namePart>Clark, Leona H.</namePart>
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<namePart>Setzer, Woodrow R.</namePart>
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<namePart>Barton, Hugh A.</namePart>
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<abstract>Proposed applications of increasinggly sophisticated biologically-based computational models, such as physiologically-based pharmacokinetic models, raise the issue of how to evaluate whether the models are adequate for proposed uses, including safety or risk assessment</abstract>
<note type="statement of responsibility">Leona H. Clark, R. Woodrow Setzer, and Hugh A. Barton</note>
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<topic>Valoración de riesgos</topic>
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<topic>Modelos de evaluación</topic>
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<topic>Análisis de riesgos</topic>
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<topic>Evaluación de riesgos</topic>
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<topic>Farmacocinética</topic>
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<title>Risk analysis : an international journal</title>
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<publisher>New York and London : Society for Risk Analysis</publisher>
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<identifier type="local">MAP20077000345</identifier>
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<text>Vol. 24, nº 6, December 2004 ; p. 1697-1717</text>
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