Airborne endotoxin associated with industrial-scale production of protein products in gram-negative bacteria

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<title>Airborne endotoxin associated with industrial-scale production of protein products in gram-negative bacteria</title>
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<title>American Industrial Hygiene Association journal</title>
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<name type="personal" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="MAPA20080251215">
<namePart>Palchak, Russell B.</namePart>
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<dateIssued encoding="marc">1988</dateIssued>
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<abstract displayLabel="Summary">Human and animal proteins of therapeutic value can be produced in E. coli, a gram-negative bacteria. Endotoxin, a cellular component, is reported to have clinically significant health effects. Operations had associated endotoxin levels ranging from 0.07 ng/m3 to 12.8 ng/m3. Utilizing a 10-fold safety factor under the threshold where clinically significant changes can be detected, an action level of 30 mg/m3 for large scale operations involving the use of E. coli was established. Operations conducted without engineering controls had maximum airborne endotoxin levels of 1812 ng/m3</abstract>
<note type="statement of responsibility">Russell B. Palchak... [et al.]</note>
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<topic>Higiene industrial</topic>
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<topic>Contaminantes químicos</topic>
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<topic>Endotoxinas</topic>
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<topic>Ambiente de trabajo</topic>
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<topic>Bacterias</topic>
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<topic>Riesgo laboral</topic>
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<title>American Industrial Hygiene Association journal</title>
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<text>Vol. 49, nº 8, August 1988 ; p. 420-421</text>
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