MAP20090074880Gibaldi, MiloBiopharmaceutics and clinical pharmacokinetics / Milo Gibaldi. — 3rd. ed. — Philadelphia : Lea & Febiger, 1984X, 330 p. ; 25 cm.Fondo donado por el Sr. Enrique González Fernández, del INSHTSumario: Introduction to pharmacokinetics -- Noncompartmental pharmacokinetics -- Gastrointestinal asorption, biologic considerations -- Gastrointestinal absorption, physicochemical considerations -- Gastrointestinal absorption, role of the dosage form -- Nonoral medication -- Prolonged-release medication -- Bioavailability -- Drug concentrations and clinical response -- Drug disposition, distribution -- Drug disposition, elimination -- Pharmacokinetic variability, body weight, age, sex, and genetic factors -- Pharmacokinetic variability, disease -- Pharmacokinetic variability, drug interactions -- Individualization and optimization of drug dosing regimens