Payer-addressable burden of crohn's disease in members treated with biologics in the United States : actuarial analysis findings from RAINBOW

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      <subfield code="a">Payer-addressable burden of crohn's disease in members treated with biologics in the United States</subfield>
      <subfield code="b">: actuarial analysis findings from RAINBOW</subfield>
      <subfield code="c">Sabyasachi Ghosh...[et al.]</subfield>
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      <subfield code="a">Payer-addressable burden (PAB) reflects how real-orld disease-associated costs impact the per member per month (PMPM) budget of a health plan, and can help to delineate drivers of PMPM costs and inform cost-management strategies for diseases with a high cost burden, such as Crohn's disease (CD). We aimed to evaluate the U.S. PAB of CD anaged with biologics. Weighted mean costs per member with CD in the commercial health plan population between 2017 and 2019 were evaluated from a health plan actuarial perspective. In addition to the overall population of members with CD treated with adalimumab, infliximab, vedolizumab, or ustekinumab, the subpopulations of members who were naive to biologic therapies at treatment initiation and/or treatment-adherent members were also analyzed. The analyses we present here highlight that treatments and patient subgroups with lower PMPM costs are important focus areas for payers in terms of identifying strategies to manage the budget for CD in a U.S. plan population</subfield>
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      <subfield code="g">04/12/2023 Tomo 27 Número 4 - 2023 , p. 619-629</subfield>
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