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Mineral fibres : correlation between oxidising surface activity and DNA base hydroxylation
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MAP20071015567
Mineral fibres : correlation between oxidising surface activity and DNA base hydroxylation / A. Nejjari... [et al.]
Sumario: In relation to their potential genotoxic propertiers, the ability of inorganic particles to induce activated species of oxygen with strong oxidative properties can be studied by various methods. In this study the oxidative surface properties of 10 different natural and synthetic mineral fibres were investigate by: an electron paramagnetic resonance technique in which formate was used to trap oxidative species; and a high performance liquid chromatography based method in which deoxyguanosine was used as a trapping agent and the formation of 8-hydroxydeoxygyanosine was analysed. Ground iron-containing fibres such as crocidolite and amosite were the most reactive, whereas fibres without iron were completely inactive. A good correlation was found when the results from the two methods were compared
En: British journal of industrial medicine. - London and Margate. - nº 6, June 1993 ; p. 501-504
1. Medicina laboral ‌. 2. Enfermedades profesionales ‌. 3. Fibra mineral ‌. 4. Higiene industrial ‌. 5. Oxidación ‌. 6. ADN ‌. I. Nejjari, A. ‌. II. Título. III. Título: British journal of industrial medicine.