Isocyanates and respiratory function : a study of workers producing polyurethane foam moulding

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      <subfield code="a">The long-term effect of isocyanates on the respiratory system has been studied in 318 workers employed in factories using isocyanates for the production of plastics. The workers were investigated by means of a questionnaire and also by pulmonary function tests of vital capacity (VC), forced expiratory volume in one second (FEV), flow volume loops, bronchial reactivity and carbon monoxide single breath transfer factor. There were no more clinical symptoms in the exposed group than in the unexposed group, but lower values of VC and of diffusion constant Kco, were observed in the exposed group, usually after long exposure. It is suggested that these workers might develop fibrosis</subfield>
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