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Detection of human exposure to electrophilic compounds by assay of thioether detoxication products in urine

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008  940215s1981 gbr|||| | |00010|eng d
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24510‎$a‎Detection of human exposure to electrophilic compounds by assay of thioether detoxication products in urine‎$c‎R. Van Doorn... [et al.]
520  ‎$a‎In this paper the possibilities of the thioether or mercapturic acid assay as a method for the detection of human exposure to electrophilic agents or their precursors are critically reviewd. The thioether assay is based on the ability of many alkalating or otherwise covalently binding compounds-a class of chemicals that includes the genotoxic compounds-to react with glutatione. Often the glutatione conjugates which are formed in this reaction are excreted in the urine as (pre)mercapturic acids or other thioethers. Thioethers can be determined spectrophotometrically after alkaline hydrolysis of urine extracts
65011‎$0‎MAPA20080585679‎$a‎Higiene industrial
65011‎$0‎MAPA20080605278‎$a‎Contaminantes químicos
65011‎$0‎MAPA20080545550‎$a‎Tioéter
65011‎$0‎MAPA20080594534‎$a‎Agentes electrófilos
65011‎$0‎MAPA20080591960‎$a‎Métodos de análisis
65011‎$0‎MAPA20080616441‎$a‎Contaminación atmosférica
65011‎$0‎MAPA20080613655‎$a‎Control de contaminantes
65011‎$0‎MAPA20080578824‎$a‎Análisis clínicos
7001 ‎$0‎MAPA20080067335‎$a‎Doorn, R. van
7404 ‎$a‎The Annals of occupational hygiene
7730 ‎$t‎The Annals of occupational hygiene‎$d‎Oxford [etc.]‎$g‎nº 1, 1981 ; p. 77-92