Detection of human exposure to electrophilic compounds by assay of thioether detoxication products in urine
<?xml version="1.0" encoding="UTF-8"?><modsCollection xmlns="http://www.loc.gov/mods/v3" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-8.xsd">
<mods version="3.8">
<titleInfo>
<title>Detection of human exposure to electrophilic compounds by assay of thioether detoxication products in urine</title>
</titleInfo>
<titleInfo type="alternative">
<title>The Annals of occupational hygiene</title>
</titleInfo>
<name type="personal" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="MAPA20080067335">
<namePart>Doorn, R. van</namePart>
<nameIdentifier>MAPA20080067335</nameIdentifier>
</name>
<typeOfResource>text</typeOfResource>
<originInfo>
<place>
<placeTerm type="code" authority="marccountry">gbr</placeTerm>
</place>
<dateIssued encoding="marc">1981</dateIssued>
<issuance>serial</issuance>
</originInfo>
<language>
<languageTerm type="code" authority="iso639-2b">eng</languageTerm>
</language>
<physicalDescription>
<form authority="marcform">print</form>
<form authority="marccategory">microform</form>
</physicalDescription>
<abstract displayLabel="Summary">In this paper the possibilities of the thioether or mercapturic acid assay as a method for the detection of human exposure to electrophilic agents or their precursors are critically reviewd. The thioether assay is based on the ability of many alkalating or otherwise covalently binding compounds-a class of chemicals that includes the genotoxic compounds-to react with glutatione. Often the glutatione conjugates which are formed in this reaction are excreted in the urine as (pre)mercapturic acids or other thioethers. Thioethers can be determined spectrophotometrically after alkaline hydrolysis of urine extracts</abstract>
<note type="statement of responsibility">R. Van Doorn... [et al.]</note>
<subject authority="lcshac" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="MAPA20080585679">
<topic>Higiene industrial</topic>
</subject>
<subject authority="lcshac" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="MAPA20080605278">
<topic>Contaminantes químicos</topic>
</subject>
<subject authority="lcshac" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="MAPA20080545550">
<topic>Tioéter</topic>
</subject>
<subject authority="lcshac" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="MAPA20080594534">
<topic>Agentes electrófilos</topic>
</subject>
<subject authority="lcshac" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="MAPA20080591960">
<topic>Métodos de análisis</topic>
</subject>
<subject authority="lcshac" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="MAPA20080616441">
<topic>Contaminación atmosférica</topic>
</subject>
<subject authority="lcshac" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="MAPA20080613655">
<topic>Control de contaminantes</topic>
</subject>
<subject authority="lcshac" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="MAPA20080578824">
<topic>Análisis clínicos</topic>
</subject>
<classification authority="">872</classification>
<relatedItem type="host">
<titleInfo>
<title>The Annals of occupational hygiene</title>
</titleInfo>
<originInfo>
<publisher>Oxford [etc.]</publisher>
</originInfo>
<part>
<text>nº 1, 1981 ; p. 77-92</text>
</part>
</relatedItem>
<recordInfo>
<recordContentSource authority="marcorg">MAP</recordContentSource>
<recordCreationDate encoding="marc">940215</recordCreationDate>
<recordChangeDate encoding="iso8601">20080418115030.0</recordChangeDate>
<recordIdentifier source="MAP">MAP20071017374</recordIdentifier>
<languageOfCataloging>
<languageTerm type="code" authority="iso639-2b">spa</languageTerm>
</languageOfCataloging>
</recordInfo>
</mods>
</modsCollection>