Accumulation of inhaled mineral dust in the lung and associated lymph nodes : implications for exposure and dose in occupational lung disease

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      <subfield code="a">Accumulation of inhaled mineral dust in the lung and associated lymph nodes</subfield>
      <subfield code="b">: implications for exposure and dose in occupational lung disease</subfield>
      <subfield code="c">J.H. Vincent... [et al.]</subfield>
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      <subfield code="a">Experiments have been carried out using laboratory rats exposed to non-fibrous, toxic and non-toxic, and relatively insoluble mineral fusts under chronic exposure conditions for airborne respirable concentrations from 0.1 to 90 mg m-3. The aim was to investigate the accumulation of dust in the lung and associated lymph nodes. The results have shown consistently that, after initial non-linear phase during the early part of the exposure history, lung burden becomes a linearly-increasing function of exposure time. Furthermore, lung burden increases directly with respect to the respirable concentration over the full range of conditions examined</subfield>
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      <subfield code="t">The Annals of occupational hygiene</subfield>
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      <subfield code="g">nº 3, 1987 ; p. 375-393</subfield>
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