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Linear systems dynamics in toxicokinetic studies

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1001 ‎$0‎MAPA20080079925‎$a‎Opdam, J.J.G.
24510‎$a‎Linear systems dynamics in toxicokinetic studies‎$c‎J.J.G. Opdam
520  ‎$a‎Linear systems are introduced to study kinetics particularly in experimental exposure to toxic agents and to extrapolate the experimental results to the field of occupational exposure. The relationship between the agent input (e.g. dose, external exposure) and the concentration-time curve [C(t)] in biological media plays a central part. When this relatioship has been established the C(t) can be predicted or the dose as function of time can be estimated retrospectively on an individual basis. The paper emphasizes the value of human exposure experiments under controlled conditions in order to verify the outcomes of physiologically based simulation models and to provide experimental data for these models
65011‎$0‎MAPA20080576615‎$a‎Medicina laboral
65011‎$0‎MAPA20080605278‎$a‎Contaminantes químicos
65011‎$0‎MAPA20080625054‎$a‎Sustancias tóxicas y peligrosas
65011‎$0‎MAPA20080592943‎$a‎Reacciones químicas
65011‎$0‎MAPA20080608286‎$a‎Reacciones metabólicas
65011‎$0‎MAPA20080559410‎$a‎Metabolismo
65011‎$0‎MAPA20080578824‎$a‎Análisis clínicos
65011‎$0‎MAPA20080552824‎$a‎Toxicidad
65011‎$0‎MAPA20080559427‎$a‎Metabolitos
7404 ‎$a‎The Annals of occupational hygiene
7730 ‎$t‎The Annals of occupational hygiene‎$d‎Oxford [etc.]‎$g‎nº 6, December 1991 ; p. 633-649