Linear systems dynamics in toxicokinetic studies

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<rdf:Description>
<dc:creator>Opdam, J.J.G.</dc:creator>
<dc:date>1991-12-01</dc:date>
<dc:description xml:lang="es">Sumario: Linear systems are introduced to study kinetics particularly in experimental exposure to toxic agents and to extrapolate the experimental results to the field of occupational exposure. The relationship between the agent input (e.g. dose, external exposure) and the concentration-time curve [C(t)] in biological media plays a central part. When this relatioship has been established the C(t) can be predicted or the dose as function of time can be estimated retrospectively on an individual basis. The paper emphasizes the value of human exposure experiments under controlled conditions in order to verify the outcomes of physiologically based simulation models and to provide experimental data for these models</dc:description>
<dc:identifier>https://documentacion.fundacionmapfre.org/documentacion/publico/es/bib/46068.do</dc:identifier>
<dc:language>eng</dc:language>
<dc:rights xml:lang="es">InC - http://rightsstatements.org/vocab/InC/1.0/</dc:rights>
<dc:subject xml:lang="es">Medicina laboral</dc:subject>
<dc:subject xml:lang="es">Contaminantes químicos</dc:subject>
<dc:subject xml:lang="es">Sustancias tóxicas y peligrosas</dc:subject>
<dc:subject xml:lang="es">Reacciones químicas</dc:subject>
<dc:subject xml:lang="es">Reacciones metabólicas</dc:subject>
<dc:subject xml:lang="es">Metabolismo</dc:subject>
<dc:subject xml:lang="es">Análisis clínicos</dc:subject>
<dc:subject xml:lang="es">Toxicidad</dc:subject>
<dc:subject xml:lang="es">Metabolitos</dc:subject>
<dc:type xml:lang="es">Artículos y capítulos</dc:type>
<dc:title xml:lang="es">Linear systems dynamics in toxicokinetic studies</dc:title>
<dc:title xml:lang="es">Título: The Annals of occupational hygiene</dc:title>
<dc:relation xml:lang="es">En: The Annals of occupational hygiene. - Oxford [etc.]. - nº 6, December 1991 ; p. 633-649</dc:relation>
</rdf:Description>
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