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Airborne endotoxin associated with industrial-scale production of protein products in gram-negative bacteria

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24510‎$a‎Airborne endotoxin associated with industrial-scale production of protein products in gram-negative bacteria‎$c‎Russell B. Palchak... [et al.]
520  ‎$a‎Human and animal proteins of therapeutic value can be produced in E. coli, a gram-negative bacteria. Endotoxin, a cellular component, is reported to have clinically significant health effects. Operations had associated endotoxin levels ranging from 0.07 ng/m3 to 12.8 ng/m3. Utilizing a 10-fold safety factor under the threshold where clinically significant changes can be detected, an action level of 30 mg/m3 for large scale operations involving the use of E. coli was established. Operations conducted without engineering controls had maximum airborne endotoxin levels of 1812 ng/m3
65011‎$0‎MAPA20080585679‎$a‎Higiene industrial
65011‎$0‎MAPA20080605278‎$a‎Contaminantes químicos
65011‎$0‎MAPA20080613617‎$a‎Contaminantes biológicos
65011‎$0‎MAPA20080558116‎$a‎Endotoxinas
65011‎$0‎MAPA20080588946‎$a‎Ambiente de trabajo
65011‎$0‎MAPA20080549855‎$a‎Bacterias
65011‎$0‎MAPA20080570484‎$a‎Riesgo laboral
7001 ‎$0‎MAPA20080251215‎$a‎Palchak, Russell B.
7400 ‎$a‎American Industrial Hygiene Association journal
7730 ‎$t‎American Industrial Hygiene Association journal‎$d‎Akron, Ohio‎$g‎Vol. 49, nº 8, August 1988 ; p. 420-421