Asbestos induced oxidative injury to DNA

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<title>Asbestos induced oxidative injury to DNA</title>
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<title>The Annals of occupational hygiene</title>
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<namePart>Mahmood, N.</namePart>
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<abstract displayLabel="Summary">DNA-damaging effects of asbestos in the presence of organic peroxides and hydroperoxides were investigated. The destabilization of the secondary structure of DNA, damage to deoxyribose sugar and DNA fidelity were measured, respectively, by S-1 nuclease hydrolysis, the formation of thiobarbituric acid (TBA)-reacting species and a melting temperature (Tm) profile using calf thymus DNA. These results suggest that asbestos in the presence of organic peroxides and hydroperoxides damage the DNA which is mediated by the generation of oxygen free radicals</abstract>
<note type="statement of responsibility">N. Mahmood... [et al.]</note>
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<text>nº 3, June 1993 ; p. 315-319</text>
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