Toxicological investigations on silicon carbide : in vitro cell tests and long term injection tests

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<title>Toxicological investigations on silicon carbide</title>
<subTitle>: in vitro cell tests and long term injection tests</subTitle>
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<title>British journal of industrial medicine</title>
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<namePart>Bruch, J.</namePart>
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<abstract displayLabel="Summary">Silicon carbide (SiC) dust and other dusts for comparison were injected intratracheally at a high dose into rats and the response of the lungs and the lymph nodes was studied after an appropriate experimental period. The indices studied were: histological changes in the lung and lymph nodes, organ weights, the formation of collagenous fibres, and the appearance of quartz typical areas. According to several epidemiological animal studies, SiC changes in the tissues studied in terms of damaging fibrogenic effects could be found after eight months and three and 12 months</abstract>
<note type="statement of responsibility">J. Bruch... [et al.]</note>
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<topic>Carburo de silicio</topic>
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<topic>Enfermedades pulmonares</topic>
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<topic>Epidemiología</topic>
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<title>British journal of industrial medicine</title>
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<publisher>London and Margate</publisher>
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<text>nº 9, September 1993 ; p. 807-813</text>
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