Accumulation of inhaled mineral dust in the lung and associated lymph nodes : implications for exposure and dose in occupational lung disease

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<title>Accumulation of inhaled mineral dust in the lung and associated lymph nodes</title>
<subTitle>: implications for exposure and dose in occupational lung disease</subTitle>
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<title>The Annals of occupational hygiene</title>
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<namePart>Vincent, James H.</namePart>
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<dateIssued encoding="marc">1987</dateIssued>
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<abstract displayLabel="Summary">Experiments have been carried out using laboratory rats exposed to non-fibrous, toxic and non-toxic, and relatively insoluble mineral fusts under chronic exposure conditions for airborne respirable concentrations from 0.1 to 90 mg m-3. The aim was to investigate the accumulation of dust in the lung and associated lymph nodes. The results have shown consistently that, after initial non-linear phase during the early part of the exposure history, lung burden becomes a linearly-increasing function of exposure time. Furthermore, lung burden increases directly with respect to the respirable concentration over the full range of conditions examined</abstract>
<note type="statement of responsibility">J.H. Vincent... [et al.]</note>
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<text>nº 3, 1987 ; p. 375-393</text>
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