Ethanol and food deprivation induced enhancement of hepatotoxicity in rats given carbon tetrachloride at low concentration

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      <subfield code="a">Ikatsu, H.</subfield>
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      <subfield code="a">Ethanol and food deprivation induced enhancement of hepatotoxicity in rats given carbon tetrachloride at low concentration</subfield>
      <subfield code="c">H. Ikatsu, T. Okino, T. Nakajima</subfield>
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      <subfield code="a">It is difficult to extrapolate the dose-response relation in CCl4 (carbon tetrachloride) induced hepatotoxicity from the high concentrations used in animal studies to the low concentrations generally encountered by man in the workplace. Therefore, the dose-response relation of inhalation exposure at low concentration must be investigated when trying to determine a TLV of exposure concentration for man. In the present study, it is investigated the dose-response relations of CCl4 induced hepatic damage in chronic ethanol treated and one day food deprived rats with biochemical and histopathological methods</subfield>
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      <subfield code="a">Tetracloruro de carbono</subfield>
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      <subfield code="a">Okino, T.</subfield>
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      <subfield code="a">British journal of industrial medicine</subfield>
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      <subfield code="t">British journal of industrial medicine</subfield>
      <subfield code="d">London and Margate</subfield>
      <subfield code="g">nº 9, September 1991 ; p. 636-642</subfield>
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