Centro de Documentacion de Fundación MAPFRE - Asbestos induced oxidative injury to DNA

MAP20071020448

Asbestos induced oxidative injury to DNA / N. Mahmood... [et al.]

Sumario: DNA-damaging effects of asbestos in the presence of organic peroxides and hydroperoxides were investigated. The destabilization of the secondary structure of DNA, damage to deoxyribose sugar and DNA fidelity were measured, respectively, by S-1 nuclease hydrolysis, the formation of thiobarbituric acid (TBA)-reacting species and a melting temperature (Tm) profile using calf thymus DNA. These results suggest that asbestos in the presence of organic peroxides and hydroperoxides damage the DNA which is mediated by the generation of oxygen free radicals

En: The Annals of occupational hygiene. - Oxford [etc.]. - nº 3, June 1993 ; p. 315-319

1. Higiene industrial . 2. Contaminantes químicos . 3. Amianto . 4. Contaminación atmosférica . 5. Oxidación . 6. Enfermedades profesionales . 7. ADN . 8. Riesgo laboral . I. Mahmood, N. . II. Título. III. Título: The Annals of occupational hygiene.