Dermal uptake of 18 dilute aqueous chemicals : in vivo disappearance-method measures greatly exceed in vitro-based predictions

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<dc:creator>Bogen, Kenneth T.</dc:creator>
<dc:date>2013-07-01</dc:date>
<dc:description xml:lang="es">Sumario: Average rates of total dermal uptake (Kup) from short-term (e.g., bathing) contact with dilute aqueous organic chemicals (DAOCs) are typically estimated from steady-state in vitro diffusion-cell measures of chemical permeability (Kp) through skin into receptor solution. Widely used (PCR-vitro) methods estimate Kup by applying diffusion theory to increase Kp predictions made by a physico-chemical regression (PCR) model that was fit to a large set of Kp measures. Here, Kup predictions for 18 DAOCs made by three PCR-vitro models (EPA, NIOSH, and MH) were compared to previous in vivo measures obtained by methods unlikely to underestimate Kup. A new PCR model fit to all 18 measures is accurate to within approximately threefold (r = 0.91, p < 10-5), but the PCR-vitro predictions (r > 0.63) all tend to underestimate the Kup measures by mean factors (UF, and p value for testing UF = 1) of 10 (EPA, p < 10-6), 11 (NIOSH, p<10-8), and 6.2 (MH, p = 0.018). For all three PCR-vitro models, log(UF) correlates negatively with molecular weight (r2 = 0.31 to 0.84, p = 0.017 to < 10-6) but not with log(vapor pressure) as an additional predictor (p > 0.05), so vapor pressure appears not to explain the significant in vivo/PCR-vitro discrepancy. Until this discrepancy is explained, careful in vivo measures of Kup should be obtained for more chemicals, the expanded in vivo database should be compared to in vitro-based predictions, and in vivo data should be considered in assessing aqueous dermal exposure and its uncertainty.</dc:description>
<dc:identifier>https://documentacion.fundacionmapfre.org/documentacion/publico/es/bib/143967.do</dc:identifier>
<dc:language>spa</dc:language>
<dc:rights xml:lang="es">InC - http://rightsstatements.org/vocab/InC/1.0/</dc:rights>
<dc:type xml:lang="es">Artículos y capítulos</dc:type>
<dc:title xml:lang="es">Dermal uptake of 18 dilute aqueous chemicals : in vivo disappearance-method measures greatly exceed in vitro-based predictions</dc:title>
<dc:relation xml:lang="es">En: Risk analysis : an international journal. - McLean, Virginia : Society for Risk Analysis, 1987-2015 = ISSN 0272-4332. - 01/07/2013 Volumen 33 Número 7 - julio 2013 </dc:relation>
</rdf:Description>
</rdf:RDF>