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Asbestos induced oxidative injury to DNA

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24510‎$a‎Asbestos induced oxidative injury to DNA‎$c‎N. Mahmood... [et al.]
520  ‎$a‎DNA-damaging effects of asbestos in the presence of organic peroxides and hydroperoxides were investigated. The destabilization of the secondary structure of DNA, damage to deoxyribose sugar and DNA fidelity were measured, respectively, by S-1 nuclease hydrolysis, the formation of thiobarbituric acid (TBA)-reacting species and a melting temperature (Tm) profile using calf thymus DNA. These results suggest that asbestos in the presence of organic peroxides and hydroperoxides damage the DNA which is mediated by the generation of oxygen free radicals
65011‎$0‎MAPA20080585679‎$a‎Higiene industrial
65011‎$0‎MAPA20080605278‎$a‎Contaminantes químicos
65011‎$0‎MAPA20080542832‎$a‎Amianto
65011‎$0‎MAPA20080616441‎$a‎Contaminación atmosférica
65011‎$0‎MAPA20080552008‎$a‎Oxidación
65011‎$0‎MAPA20080619480‎$a‎Enfermedades profesionales
65011‎$0‎MAPA20080536275‎$a‎ADN
65011‎$0‎MAPA20080570484‎$a‎Riesgo laboral
7001 ‎$0‎MAPA20080029166‎$a‎Mahmood, N.
7404 ‎$a‎The Annals of occupational hygiene
7730 ‎$t‎The Annals of occupational hygiene‎$d‎Oxford [etc.]‎$g‎nº 3, June 1993 ; p. 315-319