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Integrating the environmental and genetic architectures of aging and mortality
Integrating the environmental and genetic architectures of aging and mortality
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Section: Articles
Title: Integrating the environmental and genetic architectures of aging and mortality / M. Austin Argentieri... [et al.]
Notes: Sumario: This scientific article investigates how environmental exposures and genetic factors jointly influence aging, biological deterioration and premature mortality. Using data from nearly half a million UK Biobank participants, the study identifies 25 key environmental exposures that independently affect mortality and proteomic aging, surpassing the explanatory power of genetics. It shows how socioeconomic status, smoking, physical activity, sleep, early-life factors and ethnicity shape patterns of disease and aging. Results highlight that environmental influences explain substantially more variation in mortality than polygenic risk scoresRelated records: En: Nature Medicine . - Vol. 31, March 2025 ; p. 1016-1025Materia / lugar / evento: Genética ‌Análisis sociológico ‌Longevidad ‌Causas de la mortalidad ‌Biomarcadores ‌Envejecimiento de la población ‌Calidad de vida relacionada con la salud ‌Otros autores: Austin Argentieri, M. ‌
Other categories: 931.2
Rights: La copia digital se distribuye bajo licencia "Attribution 4.0 International (CC BY NC 4.0)"
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