Hydrogen peroxide release and hydroxyl radical formation in mixtures containing mineral fibres and human neutrophils

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      <subfield code="a">A number of recent findings support the hypothesis that reactive oxygen metabolites play an important part in the toxic effects of asbestos and other mineral fibres. For example, asbestos has been shown to catalyse the dissociation of hidrogen peroxide (H2 O2) to hidroxyde radical (OH.), and OH. formation has also been found in aqueous buffers containing asbestos without H2 O2. In these two studies, iron was considered important for catalytic activity in generation of OH.. It was thus concluded that iron mediated damage to cells could be an important mechanism in pathogenicity of asbestos</subfield>
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      <subfield code="a">British journal of industrial medicine</subfield>
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      <subfield code="t">British journal of industrial medicine</subfield>
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      <subfield code="g">nº 11, November 1992 ; p. 745-749</subfield>
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