Review of the significance of fibre size in fibre-related lung disease : a centrifuge cell for preparing accurate microscope-evaluation specimens from slurries used in inoculation studies

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      <subfield code="a">Review of the significance of fibre size in fibre-related lung disease</subfield>
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      <subfield code="a">Intratracheal, intraperitoneal inoculation studies in animals are widely used for identifying important factors in the pathogenicity of fine fibrous particles and estimating the potential of new materials to produce human pulmonary disease. Evidence on the significance of fibre size is reviewed, with emphasis on direct data derived from airborne fibres in asbestos mines and fibres retained in the miniworkers' lungs. Currents techniques are used to prepare specimens from films for light microscopy, scanning electron microscopy and the transmission electron microscopy which is so necessary for measurement of very fine fibres</subfield>
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