Centro de Documentacion de Fundación MAPFRE - Asbestos induced oxidative injury to DNA

Notas: Sumario: DNA-damaging effects of asbestos in the presence of organic peroxides and hydroperoxides were investigated. The destabilization of the secondary structure of DNA, damage to deoxyribose sugar and DNA fidelity were measured, respectively, by S-1 nuclease hydrolysis, the formation of thiobarbituric acid (TBA)-reacting species and a melting temperature (Tm) profile using calf thymus DNA. These results suggest that asbestos in the presence of organic peroxides and hydroperoxides damage the DNA which is mediated by the generation of oxygen free radicalsRegistros relacionados: En: The Annals of occupational hygiene. - Oxford [etc.]. - nº 3, June 1993 ; p. 315-319Materia / lugar / evento: Higiene industrial Contaminantes químicos Amianto Contaminación atmosférica Oxidación Enfermedades profesionales ADN Riesgo laboral Otros autores: Mahmood, N.
Títulos secundarios: Título: The Annals of occupational hygiene
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