Nonparametric bayesian methods for benchmark dose estimation

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<title>Nonparametric bayesian methods for benchmark dose estimation</title>
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<abstract displayLabel="Summary">The article proposes and investigates the performance of two Bayesian nonparametric estimation procedures in the context of benchmark dose estimation in toxicological animal experiments. The methodology is illustrated using several existing animal dose-response data sets and is compared with traditional parametric methods available in standard benchmark dose estimation software (BMDS), as well as with a published model-averaging approach and a frequentist nonparametric approach. These comparisons together with simulation studies suggest that the nonparametric methods provide a lot of flexibility in terms of model fit and can be a very useful tool in benchmark dose estimation studies, especially when standard parametric models fail to fit to the data adequately.</abstract>
<note type="statement of responsibility">Nilabja Guha...[et.al]</note>
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<title>Risk analysis : an international journal</title>
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<publisher>McLean, Virginia : Society for Risk Analysis, 1987-2015</publisher>
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<identifier type="issn">0272-4332</identifier>
<identifier type="local">MAP20077000345</identifier>
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<text>02/09/2013 Volumen 33 Número 9 - septiembre 2013 </text>
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