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Hydrogen peroxide release and hydroxyl radical formation in mixtures containing mineral fibres and human neutrophils

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<title>Hydrogen peroxide release and hydroxyl radical formation in mixtures containing mineral fibres and human neutrophils</title>
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<title>British journal of industrial medicine</title>
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<name type="personal" usage="primary" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="MAPA20080138455">
<namePart>Leanderson, Per</namePart>
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<name type="personal" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="MAPA20080233976">
<namePart>Tagesson, Christer</namePart>
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<dateIssued encoding="marc">1992</dateIssued>
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<abstract displayLabel="Summary">A number of recent findings support the hypothesis that reactive oxygen metabolites play an important part in the toxic effects of asbestos and other mineral fibres. For example, asbestos has been shown to catalyse the dissociation of hidrogen peroxide (H2 O2) to hidroxyde radical (OH.), and OH. formation has also been found in aqueous buffers containing asbestos without H2 O2. In these two studies, iron was considered important for catalytic activity in generation of OH.. It was thus concluded that iron mediated damage to cells could be an important mechanism in pathogenicity of asbestos</abstract>
<note type="statement of responsibility">Per Leanderson, Christer Tagesson</note>
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<topic>Higiene industrial</topic>
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<topic>Amianto</topic>
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<topic>Toxicología</topic>
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<subject authority="lcshac" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="MAPA20080565688">
<topic>Fibra mineral</topic>
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<topic>Sustancias químicas</topic>
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<subject authority="lcshac" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="MAPA20080585655">
<topic>Hidrógeno peróxido</topic>
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<subject authority="lcshac" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="MAPA20080580841">
<topic>Hidrógeno radical</topic>
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<topic>Acero</topic>
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<topic>Medicina laboral</topic>
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<classification authority="">872</classification>
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<title>British journal of industrial medicine</title>
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<publisher>London and Margate</publisher>
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<part>
<text>nº 11, November 1992 ; p. 745-749</text>
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