Integrating the environmental and genetic architectures of aging and mortality
Objetos digitales
| Tag | 1 | 2 | Valor |
|---|---|---|---|
| LDR | 00000caa a22000004 4500 | ||
| 001 | MAP20260007731 | ||
| 003 | MAP | ||
| 005 | 20260311132406.0 | ||
| 008 | 260311e20250219usa|||| ||| ||eng d | ||
| 040 | $aMAP$bspa$dMAP | ||
| 084 | $a931.2 | ||
| 245 | 1 | 0 | $aIntegrating the environmental and genetic architectures of aging and mortality$cM. Austin Argentieri... [et al.] |
| 520 | $aThis scientific article investigates how environmental exposures and genetic factors jointly influence aging, biological deterioration and premature mortality. Using data from nearly half a million UK Biobank participants, the study identifies 25 key environmental exposures that independently affect mortality and proteomic aging, surpassing the explanatory power of genetics. It shows how socioeconomic status, smoking, physical activity, sleep, early-life factors and ethnicity shape patterns of disease and aging. Results highlight that environmental influences explain substantially more variation in mortality than polygenic risk scores | ||
| 540 | $aLa copia digital se distribuye bajo licencia "Attribution 4.0 International (CC BY NC 4.0)"$fCC BY NC 4.0$uhttps://creativecommons.org/licenses/by-nc/4.0$964 | ||
| 650 | 4 | $0MAPA20080547424$aGenética | |
| 650 | 4 | $0MAPA20080594718$aAnálisis sociológico | |
| 650 | 4 | $0MAPA20080555016$aLongevidad | |
| 650 | 4 | $0MAPA20080609597$aCausas de la mortalidad | |
| 650 | 4 | $0MAPA20150009067$aBiomarcadores | |
| 650 | 4 | $0MAPA20080625597$aEnvejecimiento de la población | |
| 650 | 4 | $0MAPA20210021725$aCalidad de vida relacionada con la salud | |
| 700 | 1 | $0MAPA20260004723$aAustin Argentieri, M. | |
| 773 | 0 | $tNature Medicine $gVol. 31, March 2025 ; p. 1016-1025 | |
| 856 | $qapplication/pdf$w1131099$yAcceso al documento / Access the document | ||
| 856 | $uhttps://www.nature.com/articles/s41591-024-03483-9 |