Integrating the environmental and genetic architectures of aging and mortality

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<title>Integrating the environmental and genetic architectures of aging and mortality</title>
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<namePart>Austin Argentieri, M.</namePart>
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<abstract displayLabel="Summary">This scientific article investigates how environmental exposures and genetic factors jointly influence aging, biological deterioration and premature mortality. Using data from nearly half a million UK Biobank participants, the study identifies 25 key environmental exposures that independently affect mortality and proteomic aging, surpassing the explanatory power of genetics. It shows how socioeconomic status, smoking, physical activity, sleep, early-life factors and ethnicity shape patterns of disease and aging. Results highlight that environmental influences explain substantially more variation in mortality than polygenic risk scores</abstract>
<accessCondition type="use and reproduction">La copia digital se distribuye bajo licencia "Attribution 4.0 International (CC BY NC 4.0)"</accessCondition>
<note type="statement of responsibility">M. Austin Argentieri... [et al.]</note>
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<topic>Genética</topic>
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<topic>Análisis sociológico</topic>
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<topic>Longevidad</topic>
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<topic>Causas de la mortalidad</topic>
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<topic>Biomarcadores</topic>
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<topic>Envejecimiento de la población</topic>
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<topic>Calidad de vida relacionada con la salud</topic>
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<url displayLabel="electronic resource">https://www.nature.com/articles/s41591-024-03483-9</url>
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<title>Nature Medicine</title>
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<text>Vol. 31, March 2025 ; p. 1016-1025</text>
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